Plant in full sun in a well-drained soil and water infrequently if at all in Southern California - might not be good in areas that get more rainfall but should prove hardy to mild frosts.

Agave subsimplex is a rare agave that comes from three scattered locations along the coast of the Sea of Cortez in the Mexican state of Sonora - in its native habitat it has become threatened by coastal urban development and is classified as Vulnerable on the International Union for Conservation of Nature (IUCN) Red List of Threatened Species. The specific epithet from Latin 'sub' meaning "almost" or "more or less" and 'simplex' meaning "simple" is thought to have been derived from the observation that the plants are only sometimes suckering, but in cultivation it seems that this species the suckering nature might be more common. This name might cause some confusion with Agave simplex, a plant recently promoted to species level that was previously considered a variety of Agave deserti.

Our plants grown from seed given to us that was collected 15 km south of Puerto Libertad in the Mexican State of Sonora and we sold the plant from 2023 until we closed the nursery in 2025. 

Information displayed on this page about Agave subsimplex is based on our research conducted about this plant in our nursery library as well as from information provided by reliable online resources. We also include our own observations made about it as it has grown in the nursery gardens and other gardens visited, as well how the crops of this plant performed in the containers in our nursery field. We will also include comments received from others and welcome hearing from anyone who has information about this plant, particularly if it includes cultural information aiding others to better grow it.