Plant in full sun and water occasionally to infrequently. Winter hardiness is as yet not well documented but the Ruth Bancroft Garden, which experiences mid to high 20s° F temperatures each year has protected this species in by covering it each winter. Plants in our nursery have experienced brief winter temperatures down to just below 31° F without damage. This species is one of the least common of Uganda aloes.

Aloe wrefordii grows only in a tiny population near Moroto in the Karamoja District of the Northern Province of Uganda where it grows within thornbushes and exposed rocky slopes from 3,100 to 4,700 feet in elevation. The name Aloe comes from ancient Greek name aloe that was derived from the Arabian word 'alloch' that was used to describe the plant or its juice that was used as medicine. This plants specific epithet honors Herbert Wreford-Smith (1890–1962), a farmer and naturalist in Kenya and Uganda. Our plants from wild seed collected by Tom Cole of Cold Springs Aloes in 2014. 

Information displayed on this page about Aloe wrefordii is based on our research conducted about this plant in our nursery library as well as from information provided by reliable online resources. We also include our own observations made about it as it has grown in the nursery gardens and other gardens visited, as well how the crops of this plant performed in the containers in our nursery field. We will also include comments received from others and welcome hearing from anyone who has information about this plant, particularly if it includes cultural information aiding others to better grow it.