Plant in full sun in a well-drained soil. This plant should prove to be a very drought tolerant plant but likely will grow faster and considerably larger when given regular irrigation. Cold hardiness of this species has yet to be determined but it has weathered temperatures down to 31° F at our location without damage.

Agave gypsicola is only known from the Upper basin of the Río Verde, Tlaxiaco district in Oaxaca, where it grows on slopes with gypsum soils from 4,500 to 5,200 feet in elevation. The plants provided to us were grown from seed collected from a particularly pale gray colored plant. Agave gypsicola is considered to be closely related to Agave guiengola, which it differs from by having flatter and shorter ovate to semi-orbicular leaves. It was described in 2019 by Mexican botanists Abisai Garcia-Mendoza Daniel Sandoval in Acta Botanica Mexicana. The specific epithet refers to the plant growing on gypsum soils. The Mixtec people refer to this plant as Senizo, which means "ashen" in reference to its silvery to bluish-white color, though greener plants also occur within this same population. The picture on this page taken in this plant's natural habitat near Teita, is courtesy of Tony Krock. 

Information displayed on this page about Agave gypsicola is based on our research conducted about this plant in our nursery library as well as from information provided by reliable online resources. We also include our own observations made about it as it has grown in the nursery gardens and other gardens visited, as well how the crops of this plant performed in the containers in our nursery field. We will also include comments received from others and welcome hearing from anyone who has information about this plant, particularly if it includes cultural information aiding others to better grow it.